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Vascular Biomarkers: What is Pulse Pressure?

Vascular Biomarkers: What is Pulse Pressure?

Systolic pressure refers to the maximum pressure of the heart when beating.

When the heart relaxes between heartbeats, we call this pressure diastole. Pulse pressure represents the difference between systolic and diastolic blood pressure. The higher the central pulse pressure, the greater the pressure exerted on organs such as the heart, brain, and kidneys. In addition to increasing the risk of heart and circulatory problems, studies show elevated central aortic pulse pressure can independently predict end organ damage like renal failure and Alzheimer’s.

What Is a Normal Pulse Pressure?

If your resting blood pressure is 120/80 millimeters of mercury (mm Hg), your pulse pressure is 40. We consider this a normal, healthy pulse pressure. Monitor any pulse pressure reading over 40 mm Hg, as it could indicate an early warning sign of an increased risk of heart attack, stroke, or other circulatory problems. Studies show an increase in pulse pressure as minor as 10 mm Hg can elevate the risk of heart disease by 20 percent.

What Causes a High Pulse Pressure?

As people age, their arteries naturally stiffen. The process of arterial stiffening can be accelerated by negative lifestyle factors such as a poor diet, smoking, and a sedentary lifestyle. The stiffer the arteries, the faster blood moves through the circulatory system. As a strong pulse wave of blood moves from the aorta to the narrow capillaries, it hits a wall and some of this blood gets reflected back to the heart prematurely while the organ is still trying to push out out blood (systole). This puts an enormous strain on the heart.

How is Central Pulse Pressure Measured?

Until recently, professionals could only measure this sophisticated vascular biomarker within a professional setting. By combining a traditional brachial cuff with wave form analysis to measure pulse pressure non-invasively, CONNEQT Pulse allows users to measure central pulse pressure from the comfort of their own home in just over five minutes. Results automatically sync to a HIPPA compliant, fully encrypted patient portal that physicians can monitor remotely.

Sources

O’Rourke, M. F., Safar, M. E. The Relationship Between Increased Central Arterial Stiffness and Cardiovascular Disease. Hypertension. 2002; doi:10.1161/hypertensionaha.107.093740.

Vlachopoulos, C., Aznaouridis, K., Stefanadis, C. Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness. Journal of the American College of Cardiology. 2010; doi:10.1016/j.jacc.2010.04.052.

Sharman, J. E., Stowasser, M., Fassett, R. Central Blood Pressure Measurement in the Management of Hypertension. Journal of Hypertension. 2006; doi:10.1097/01.hjh.0000222742.01439.8d.

Benetos, A., Thomas, F., Bean, K., et al. Role of Modifiable Risk Factors in the Development of Arterial Stiffness in Adults: A Cross-Sectional Study. Hypertension. 2002; doi:10.1161/01.HYP.0000032640.71088.66.

Pierce, G. L., Casey, D. P., Seals, D. R. Aerobic Exercise and Arterial Aging: Clinical Implications. Hypertension. 2011; doi:10.1161/HYPERTENSIONAHA.111.177535.

American Heart Association. Physical Activity Recommendations for Adults. Available at: heart.org.

van Sloten, T. T., Schram, M. T., van den Hurk, K., et al.Arterial Stiffness and Risk of Type 2 Diabetes: The Maastricht Study. Hypertension. 2022; doi:10.1161/hypertensionaha.120.16584.

Kim, H., Kim, K., Shin, J., et al. The Effects of Stress on Arterial Stiffness in Korean Americans. Journal of Hypertension. 2015; doi:10.1097/HJH.0000000000000468.

Holick, M. F., Chen, T. C. Vitamin D Deficiency: A Worldwide Problem With Health Consequences. American Journal of Clinical Nutrition. 2008; doi:10.1093/ajcn/87.4.1080S.

Nature Reviews. Smoking and Cardiovascular Health: A Global Perspective. Nature Reviews Cardiology. 2010; doi:10.1038/nrcardio.2010.104.

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