Renal Disease

Navigate Therapies for Chronic Kidney Disease Management

with Digital Vascular Biomarkers

Fast Fact

37M

Kidney disease affects an estimated 37 million people in the US.1

Renal Disease & Arterial Stiffening Go Hand-in-Hand

Arterial Stiffness and Renal Function

Arterial stiffness reduces artery elasticity, exerting continuous high pressure on kidney vessels, damaging them, and potentially hastening chronic kidney disease progression. As kidney function worsens, its regulation of blood pressure and fluid balance declines, further increasing arterial stiffness and creating a harmful feedback loop. Epidemiological evidence links arterial stiffness with greater renal impairment risks, highlighting the need for interventions like lifestyle adjustments and blood pressure management to mitigate these effects and maintain renal health.

Research Highlights

Optimize Renal Disease Management

Vascular biomarkers are crucial for managing renal disease, providing insights into patients' cardiovascular health through measures like arterial stiffness, augmentation index, and central blood pressure. These indicators help assess cardiovascular risk, monitor disease progression, and guide treatment strategies, including the adjustment of antihypertensive medications and lifestyle changes. 

By enabling personalized treatment plans based on individual vascular profiles, vascular biomarkers are vital for predicting outcomes, optimizing renal disease management, and minimizing cardiovascular complications to enhance patient care.

Utility of Vascular Biomarkers in Renal Disease

  • Kirkham FA, Rankin P, Parekh N, Holt SG, Rajkumar C

    Aortic stiffness and central SBP are independently associated with orthostatic SBP fall in CKD patients. This suggests that enhanced arterial stiffness may be an underlying mechanism in baroreflex dysfunction, and may partly explain the vascular risk in CKD patients.

    Kirkham FA, Rankin P, Parekh N, Holt SG, Rajkumar C
    Observational Study
  • Debowska M, Poleszczuk J, Dabrowski W, Wojcik-Zaluska A, Zaluska W, Waniewski J.

    Hemodialysis affected cardiovascular system with the parameters derived from pulse-wave-analysis (systolic and augmented pressures, pulse height, ejection duration, SEVR) being significantly different at the end of dialysis from those before the session. Combination of pulse-wave-analysis with the monitoring of overhydration provides a new insight into the impact of hemodialysis on cardiovascular system.

    Debowska M, Poleszczuk J, Dabrowski W, Wojcik-Zaluska A, Zaluska W, Waniewski J.
    PLoS One
  • Cai R, Shao L, Zhu Y, Liu Y, Zhang J, He Q

    [Central Pulse Pressure] is a better parameter for predicting the occurrence of LVH in patients with CKD.

    Cai R, Shao L, Zhu Y, Liu Y, Zhang J, He Q
    Nephrology

Incorporate Vascular Biomarkers in the Management of Chronic Kidney Disease

Download Reimbursement Guide

In-Clinic

  • Refine risk stratification and management plans for CKD patients.
  • Use vascular biomarker results to tailor therapeutic strategies.
  • Reimbursable with CPT 93050.

At Home

  • Track the progression of disease and the impact of hemodialysis on cardiovascular system.
  • Integration with telemedicine enables ongoing patient-provider interaction and enhances personalized care.
  • Reimbursable with CPT 9945x & 99091.

1 CDC Chronic Kidney Disease Basics